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New Product - Gastric Function Test - Pepsinogen I/II(PGI/II

Published: 2019-01-29| Size:L M S|

1.Pepsinogen

Pepsinogen (PG) is the precursor of pepsin secreted by the stomach and involved in digestion. Generally, 1% of PG can enter the blood circulation through the gastric mucosa, which can be divided into two subtypes: PGI and PGII

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Serum pepsinogen can accurately show the state and function of gastric mucosa

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Pepsinogen I is secreted by the main cells and cervical mucus cells of the gastric fundus gland

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Pepsinogen II can be produced in the pyloric and duodenal glands in addition to the secretion of the host cells and cervical mucus cells

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2.Biological Function Of Pepsinogen

With the development of gastric disease, PGI in serum first increases, then decreases, and then increases, and then maintains a higher level. Thus, the abnormal PGI / PGII ratio of PGI and PGII will indicate the different course of gastric disease and become the primary screening index and monitoring index of treatment for gastric diseases

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3.Main Clinical Significance

bob综合网页版:A. Early screening of gastric cancer

B. Screening of gastric ulcer, atrophic gastritis and HP infection

C. Evaluation of therapeutic effect of Helicobacter pylori (HP)

D. Criteria for recurrence and cure of peptic ulcer

bob综合网页版:E. Criteria of recurrence after gastrectomy

F. Dynamic examination of gastric mucosa function

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4.Who is suitable for PGI / PGII

bob综合网页版:Helicobacter pylori infection

bob综合网页版:Male, especially over 2025kg

bob综合网页版:50 to 80

bob综合网页版:Salt, pickled vegetables, bacon and fish

bob综合网页版:Smoke

bob综合网页版:Old stomach with gastric operation and polyp

Family cancer, family history of gastric cancer

bob综合网页版:Pernicious anemia

bob综合网页版:Type A blood

Long term working with a lot of smoke, asbestos and nickel ring


5.Reference Norm

PGI normal reference value range is 70-200ng / ml

PGII normal reference value range is 0-15ng / ml

bob综合网页版:PGI/ PGII7.5

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bob综合网页版:Applicable Platform

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